Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (IDH) mutants and IDH wild-types (IDH-wt). This study aimed at identifying the mutational assets of IDH-wt GBMs in patients aged 18-54 years for which limited data are available.

Ultra-Mutation in IDH Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment

Barresi, Valeria
;
Simbolo, Michele;Mafficini, Andrea;Piredda, Maria Liliana;Cingarlini, Sara;Ghimenton, Claudio;Scarpa, Aldo
2019-01-01

Abstract

Glioblastomas (GBMs) are classified into isocitrate dehydrogenase (IDH) mutants and IDH wild-types (IDH-wt). This study aimed at identifying the mutational assets of IDH-wt GBMs in patients aged 18-54 years for which limited data are available.
IDH wild-type; POLE; giant cells; glioblastoma; mismatch repair; tumour mutation load
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/999965
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