With the final aim to correlate molecular/expression profile of surgically-resected LNET with their prognosis and therefore attempt to establish a more effective treatment strategy, Ichiki et al. performed an IHC analysis of neuroendocrine markers and programmed cell death-ligand 1 (PD-L1) in 105 pulmonary NET. The PD-L1 expression did not significantly predict prognosis, while a trend correlating the higher expression of the neuroendocrine markers chromogranin A and synaptophysin with a worse survival outcome was reported, leading the authors to speculate that these IHC analyses may assist clinicians in the decision about adjuvant chemotherapy or follow-up intervals after surgery (13). Although the limited and retrospective nature, this study provided new insights about LNET with potential clinico-therapeutical implications to be further validated.
Exploring the molecular and biological background of lung neuroendocrine tumours
Simbolo, Michele;Milella, Michele;Scarpa, Aldo;Tortora, Giampaolo;Bria, Emilio;Pilotto, Sara
2019-01-01
Abstract
With the final aim to correlate molecular/expression profile of surgically-resected LNET with their prognosis and therefore attempt to establish a more effective treatment strategy, Ichiki et al. performed an IHC analysis of neuroendocrine markers and programmed cell death-ligand 1 (PD-L1) in 105 pulmonary NET. The PD-L1 expression did not significantly predict prognosis, while a trend correlating the higher expression of the neuroendocrine markers chromogranin A and synaptophysin with a worse survival outcome was reported, leading the authors to speculate that these IHC analyses may assist clinicians in the decision about adjuvant chemotherapy or follow-up intervals after surgery (13). Although the limited and retrospective nature, this study provided new insights about LNET with potential clinico-therapeutical implications to be further validated.
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