NOCTURIA IN MALES WITH LUTS: PREVALENCE AND COMPARISON BETWEEN INTERNATIONAL PROSTATE SYMPTOM SCORE AND FREQUENCY-VOLUME CHARTS. AN OBSERVATIONAL, PROSPECTIVE DOUBLE-CENTRE STUDY

METHODS. An observational, prospective study was performed involving two Urological Departments. 461 consecutive male patients with LUTS were recruited from September 2016 to November 2017. The following data were recorded: demographic characteristics, urological history, and self-administered IPSS. They were requested to complete a 3-days FVC, indicating “bedtime” and “waking time”. The mean number of nightly voids was correlated to IPSS domains, in particular to: i) IPSS nocturia score (domain 7), ii) total IPSS score (domains 1-7), iii) IPSS quality of life score (domain 8). Statistical analysis was performed using T student and Mann-Whitney test and Bravais-Pearson correlation test. RESULTS 162/461 patients (35%) completed both IPSS and 3-days FVC (mean age 70,95 ± 8.04 years). Prevalence of reported nocturia was 86,42%, with a mean number of nocturnal voiding of 1.36 ± 0,98 per night. Figure 1 shows distribution of mean episodes of nocturnal voiding per night. Figure 2 documents the difference in mean episodes of nocturia between IPSS and 3-days FVC (absolute values). The differences in episodes of nocturnal voiding between IPSS and 3-days FVC according to patients age are reported in Table 1. Table 2 shows the comparison of median IPSS domains 7, 8 and IPSS total score according to average number of nocturia episodes on the 3-days FVC. Considering a threshold of 70 years of age, no significant difference was found in episodes of nocturnal voiding between IPSS and mean number of nocturnal voiding at 3-days FVC according to patients age (Table 3). Median IPSS domain 7 and total IPSS score were higher when the mean number of night voids was > 1 (p<0.001). IPSS domain 8 did not reach any statistical difference (p>0.05). Bravais-Pearson correlation test showed a moderate positive correlation (+0,42) between the mean number of nightly voids on the 3-days FVC and IPSS 7.