Statin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large. Previous association studies of common genetic variants have had limited success in identifying a genetic basis for this adverse drug reaction. We conducted a multi-site whole-exome sequencing study to investigate whether rare coding variants confer an increased risk of SRM.

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing

Conforti, Anita;
2019-01-01

Abstract

Statin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large. Previous association studies of common genetic variants have had limited success in identifying a genetic basis for this adverse drug reaction. We conducted a multi-site whole-exome sequencing study to investigate whether rare coding variants confer an increased risk of SRM.
GENETIC VARIANT, Muscular Diseases, Pharmacokinetics, Statin-induced myopathy
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/996665
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