The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD.

In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias

Ranieri, F;
2006

Abstract

The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD.
Alzheimer, frontotemporal dementia, acetylcholine, motor cortex, transcranial magnetic stimulation, TMS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/996640
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