Low dose acitretin versus methotrexate in the treatment of palmoplantar psoriasis: a case series.

Palmoplantar psoriasis (PP) is a localized form of psoriasis presenting with thick and scaly plaques commonly with painful and bleeding fissures involving the palms and soles.1–3 The treatment of PP is generally challenging because of resistance to treatments.4 Methotrexate and acitretin have been compared in the treatment of PP, with a superiority of methotrexate at week 12.5 However, their effectiveness could be higher if the treatment period is longer than 12 weeks and adverse events could be less common if used at lower dose. The objective of this retrospective study was to investigate the efficacy and safety of low dose acitretin versus methotrexate in PP.