Glomerular filtration rate in patients with moderate-to-severe psoriasis.

Psoriasis could be associated to comorbidities that can affect kidney function, including diabetes mellitus, arterial hypertension and hyperuricaemia.1,2 Chronic kidney disease (CKD) affects up to 10.4% of patients with psoriasis,3–5 and it is a risk factor for renal failure, cardiovascular diseases and overall mortality. 6 Cyclosporine could be nephrotoxic, whereas methotrexate and biologics are not considered to affect kidney function,7 although studies investigating their effect on glomerular filtration rate (GFR) are scarce.8 The objective of this retrospective study was to estimate GFR in patients with psoriasis and GFR reduction during systemic treatment.