DNA mutational profiling showed that atypical carcinoids (ACs) share alterations with large-cell neuroendocrine carcinomas (LCNECs). Transcriptomic studies suggested that LCNEC are composed of two subtypes, one of which shares molecular anomalies with small-cell lung cancer. The missing piece of information is the transcriptomic relationship between AC and LCNEC, as a direct comparison is lacking in literature.

Gene expression profiling of lung atypical carcinoids and large cell neuroendocrine carcinomas identifies three transcriptomic subtypes with specific genomic alterations

Simbolo, Michele;Barbi, Stefano;Fassan, Matteo;Mafficini, Andrea;Vicentini, Caterina;Sperandio, Nicola;Corbo, Vincenzo;Rusev, Borislav;Pilotto, Sara;Pelosi, Giuseppe;Lawlor, Rita T;Tortora, Giampaolo;Scarpa, Aldo;Bria, Emilio
2019

Abstract

DNA mutational profiling showed that atypical carcinoids (ACs) share alterations with large-cell neuroendocrine carcinomas (LCNECs). Transcriptomic studies suggested that LCNEC are composed of two subtypes, one of which shares molecular anomalies with small-cell lung cancer. The missing piece of information is the transcriptomic relationship between AC and LCNEC, as a direct comparison is lacking in literature.
Lung neuroendocrine tumours; atypical carcinoid; gene expression profiling; large cell neuroendocrine carcinoma; next-generation sequencing; transcriptomics
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/995282
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