Activated signal transducer and activator of transcription 3 (STAT3) regulates tumor growth, invasion, cell proliferation, angiogenesis, immune response, and survival. Data regarding expression of phosphorylated (activated) STAT3 in diffuse large B-cell lymphoma (DLBCL) and the impact of phosphorylated STAT3 (pSTAT3) on prognosis are limited.

Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma

Visco, Carlo;Bertoni, Francesco;
2014-01-01

Abstract

Activated signal transducer and activator of transcription 3 (STAT3) regulates tumor growth, invasion, cell proliferation, angiogenesis, immune response, and survival. Data regarding expression of phosphorylated (activated) STAT3 in diffuse large B-cell lymphoma (DLBCL) and the impact of phosphorylated STAT3 (pSTAT3) on prognosis are limited.
2014
Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Cyclin D1; Cyclophosphamide; Doxorubicin; Female; Gene Expression; Genes, bcl-2; Genes, myc; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; NF-kappa B; Neoplasm Metastasis; Neoplasm Staging; Phosphorylation; Prednisone; Prognosis; Proto-Oncogene Proteins c-akt; STAT3 Transcription Factor; Signal Transduction; Tumor Burden; Tumor Suppressor Protein p53; Vincristine
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/993471
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