Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary.

Autoimmune cytopenias in chronic lymphocytic leukemia

Visco, Carlo;
2014-01-01

Abstract

Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary.
Adrenal Cortex Hormones; Agranulocytosis; Anemia, Hemolytic, Autoimmune; Antigen Presentation; Autoantibodies; Blood Cells; Blood Component Transfusion; Clone Cells; Combined Modality Therapy; Humans; Immunoglobulin G; Immunoglobulin Heavy Chains; Immunoglobulin M; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Models, Immunological; Neoplastic Stem Cells; Paraneoplastic Syndromes; Prognosis; Purpura, Thrombocytopenic, Idiopathic; Receptors, Antigen, B-Cell; Red-Cell Aplasia, Pure; Risk Factors; Splenectomy; T-Lymphocyte Subsets
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/993469
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