Crohn's disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety and possible efficacy of mesenchymal stem cells (MSCs) as a new therapeutic tool for this condition. Therefore, we aimed to investigate the effects of bone marrow-derived MSCs on pathogenic T cells with a view to clinical application.

Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn's disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact

Ciccocioppo, Rachele;
2015-01-01

Abstract

Crohn's disease (CD) is a disabling chronic enteropathy sustained by a harmful T-cell response toward antigens of the gut microbiota in genetically susceptible subjects. Growing evidence highlights the safety and possible efficacy of mesenchymal stem cells (MSCs) as a new therapeutic tool for this condition. Therefore, we aimed to investigate the effects of bone marrow-derived MSCs on pathogenic T cells with a view to clinical application.
2015
Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Surface; Apoptosis; Bone Marrow Cells; Cell Proliferation; Cell Survival; Cells, Cultured; Coculture Techniques; Crohn Disease; Cytokines; Female; HLA-G Antigens; Humans; Immunophenotyping; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Male; Mesenchymal Stem Cells; Middle Aged; RNA Interference; RNA, Small Interfering; T-Lymphocytes; Time-Lapse Imaging; Tryptophan; Young Adult
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/991917
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