Correlation between gastroesophageal reflux and respiratory sounds in children.

irty-eight children (aged>24 months) with symptoms of gastroesophageal re ux and/or wheezing and cough were enrolled in this study. Patients underwent pH-impedance monitoring and recording of lung sounds (WHolter®). Results: e median number of cough events associated with weakly acid re ux in the group of patients with positive impedance monitoring was signi cantly higher than the median of cough associated with weakly acid and non-acid re ux in the group of patients with negative impedance monitoring (p = 0.003). e median number of events of wheezing ≥5% associated with an episode of acid re ux was signi cantly higher (p = 0.008) in the group of patients with positive 24-hr pH monitoring than those with negative 24-hr pH monitoring. Conclusion: In conclusion, we found a relationship between gastroesophageal re ux and respiratory symptoms: wheezing was associated mainly with acid re ux, whereas coughing was associated with weakly acid re ux.