Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP

Zavala-Tecuapetla, Cecilia; Kubová, Hana; Otáhal, Jakub; Tsenov, Grygoriy; Mareš, Pavel

doi:10.1016/j.pharep.2014.02.018

Action of an antagonist of metabotropic glutamate receptors subtype 5 MTEP was studied in a model of complex partial seizures. Dorsal hippocampus of rat pups 12, 18 and 25 days old was stimulated six times with 10-min intervals. MTEP (20 or 40 mg/kg) was injected after the first afterdischarge and duration of afterdischarges was measured. MTEP exhibited marked anticonvulsant action in 12-day-old-rats, the similar effect in 18-day-old rats was observed only with the second stimulation. No anticonvulsant action was seen in 25-day-old animals. Our results may qualify antagonists of mGluR5 as potential antiepileptic drugs for some types of childhood epilepsies.

Titolo:	Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP
Autori:	Zavala-Tecuapetla, Cecilia Kubová, Hana Otáhal, Jakub Tsenov, Grygoriy Mareš, Pavel (Corresponding) mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	PHARMACOLOGICAL REPORTS
Handle:	http://hdl.handle.net/11562/990280
Appare nelle tipologie:	01.01 Articolo in Rivista

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http://hdl.handle.net/11562/990280

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