d-Cycloserine, a partial NMDA agonist, significantly accelerated extinction of a cocaine-induced conditioned place preference (CPP) when rats were given systemic injections immediately, but not 4h, after each extinction trial. Infusions directly into the basolateral amygdala had a similar effect. The facilitative effect of d-cycloserine on the extinction of appetitive conditioning is consistent with the idea of the formation of new learned associations during extinction.

d-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference

Paolone G
Conceptualization
;
2006

Abstract

d-Cycloserine, a partial NMDA agonist, significantly accelerated extinction of a cocaine-induced conditioned place preference (CPP) when rats were given systemic injections immediately, but not 4h, after each extinction trial. Infusions directly into the basolateral amygdala had a similar effect. The facilitative effect of d-cycloserine on the extinction of appetitive conditioning is consistent with the idea of the formation of new learned associations during extinction.
d-cycloserine, cocaine, conditioned place preference, reward, extinction
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/988610
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