PURPOSE: We report a case of large colloid drusen complicated by extensive quiescent choroidal neovascularization in both eyes. METHODS: Case report. RESULTS: A 46-year old woman was referred to our department with diagnosis of early-onset retinal drusen. Review of examinations performed 16 years before along with current multimodal imaging evaluation showed the presence of numerous large colloid drusen, subsequently replaced by quiescent choroidal neovascularization in both eyes, nicely visualized by optical coherence tomography angiography. CONCLUSION: This case suggests progressive development of quiescent neovascularization beneath the drusen as a possible late evolution of degenerating large colloid drusens.
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