Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and VEGF-R1 expression, was encountered in this tumor. By contrast, the anti-angiogenic factor semaphorin3A, highly expressed in this chordoid meningioma, was ineffective because of the absence of its receptor neuropilin-1. We suggest that VEGF expression and MVD may represent significant prognostic factors in chordoid meningiomas.
Titolo: | Evaluation of neo-angiogenesis in a case of chordoid meningioma |
Autori: | |
Data di pubblicazione: | 2009 |
Rivista: | |
Handle: | http://hdl.handle.net/11562/986328 |
Appare nelle tipologie: | 01.01 Articolo in Rivista |