Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade.
Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models
DEL CURATOLO, ANAIS;Corbo, Vincenzo;D'Agosto, Sabrina;Scarpa, Aldo;Milella, Michele;
2018-01-01
Abstract
Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade.
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