Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade.

Therapeutic potential of combined BRAF/MEK blockade in BRAF-wild type preclinical tumor models

DEL CURATOLO, ANAIS;Corbo, Vincenzo;D'Agosto, Sabrina;Scarpa, Aldo;Milella, Michele;
2018-01-01

Abstract

Mounting evidence suggests that RAF-mediated MEK activation plays a crucial role in paradox MAPK (re)activation, leading to resistance and therapeutic failure with agents hitting a single step along the MAPK cascade.
BRAF; Combination therapy; MAPK; MEK; Paradoxical effect
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/983403
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