Basophil activation test in a case report of cow's milk allergy may reveal a non-IgE mediated mechanism

In a very recent article on this journal Schocker et al., wondered if a series of allergic persistent reaction in breast-fed newborns, showing allergy to cow's milk, should be explained by a primary sensitization to human breast milk or by a cross-reactivity with cow's milk proteins1 . The authors conducted an interesting study on a 29-years old adult, who experienced such allergic pattern when he was a breast-fed baby, then experienced anaphylaxis and cardioplegia during his childhood and due to the severity of his food allergy, underwent oral immunotherapy (OIT), with an adjunctive treatment with omalizumab1 . A possible cross-reactivity between cow's and human's casein, mainly β-casein, has been suggested in this case report. This article is protected by copyright. All rights reserved.