Anaphylactic Reactions After Discontinuation of Hymenoptera Venom Immunotherapy: A Clonal Mast Cell Disorder Should Be Suspected

Up to 75% of patients with severe anaphylactic reactions after Hymenoptera sting are at risk of further severe reactions if re-stung. Venom immunotherapy (VIT) is highly effective in protecting individuals with ascertained Hymenoptera venom allergy (HVA) and previous severe reactions. After a 3- to 5-year VIT course, most patients remain protected after VIT discontinuation. Otherwise, a lifelong treatment should be considered in high-risk patients (eg, in mastocytosis). Several case reports evidenced that patients with mastocytosis and HVA, although protected during VIT, can re-experience severe and sometimes fatal reactions after VIT discontinuation.

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Titolo: Anaphylactic Reactions After Discontinuation of Hymenoptera Venom Immunotherapy: A Clonal Mast Cell Disorder Should Be Suspected
Autori: 
BONADONNA, PATRIZIA
ZANOTTI, ROBERTA
BONIFACIO, Massimiliano
SCAFFIDI, Luigi
OLIVIERI, ELISA
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Data di pubblicazione: 2017
Rivista: 
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE  
Handle: http://hdl.handle.net/11562/977821
Appare nelle tipologie:01.01 Articolo in Rivista

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http://hdl.handle.net/11562/977821
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