Pancreatic cancer is one of the most threatening and poorly understood human malignancies. MEKK3 (MAP3K3) is a serine/threonine kinase activated by different signaling pathways. YAP and TAZ are critical oncogenic effectors in pancreatic cancer. We hypothesized that MEKK3 could sustain pancreatic cancer by inducing YAP/TAZ oncogenic activities.

MEKK3 Sustains EMT and Stemness in Pancreatic Cancer by Regulating YAP and TAZ Transcriptional Activity

Santoro, Raffaela;Zanotto, Marco;Carbone, Carmine;Piro, Geny;Tortora, Giampaolo;Melisi, Davide
2018-01-01

Abstract

Pancreatic cancer is one of the most threatening and poorly understood human malignancies. MEKK3 (MAP3K3) is a serine/threonine kinase activated by different signaling pathways. YAP and TAZ are critical oncogenic effectors in pancreatic cancer. We hypothesized that MEKK3 could sustain pancreatic cancer by inducing YAP/TAZ oncogenic activities.
2018
MEKK3; TAZ; YAP; pancreatic cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/977286
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