Nowadays, the assessment of brain functional connectivity (FC) patterns, ranging from resting-state networks to network modelling, can rely on Arterial Spin Labeling (ASL) MRI as an alternative to the gold-standard sequence represented by the blood-oxygenation-level-dependent contrast. We have evaluated these aspects from different point of view (experimental protocols, populations and analysis methods), trying to overcome some of the present challenges related to the ASL applicability in this context. The results demonstrate how FC patterns and changes can be reliably detected using ASL, with the added value of allowing the simultaneous quantification of brain perfusion, i.e. a marker of neuronal activity.
Probing functional connectivity and network modelling from perfusion neuroimaging with Arterial Spin Labeling
Ilaria Boscolo Galazzo
;Silvia Francesca Storti;Francesca Benedetta Pizzini;Claudio Tomazzoli;Gloria Menegaz
2018-01-01
Abstract
Nowadays, the assessment of brain functional connectivity (FC) patterns, ranging from resting-state networks to network modelling, can rely on Arterial Spin Labeling (ASL) MRI as an alternative to the gold-standard sequence represented by the blood-oxygenation-level-dependent contrast. We have evaluated these aspects from different point of view (experimental protocols, populations and analysis methods), trying to overcome some of the present challenges related to the ASL applicability in this context. The results demonstrate how FC patterns and changes can be reliably detected using ASL, with the added value of allowing the simultaneous quantification of brain perfusion, i.e. a marker of neuronal activity.
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