Time is of the essence: The rotational motion of biomolecules depends on intra- and intermolecular interactions and thus on distinct functional states. A new method, called HYCUD accurately predicts rotational correlation times in complex dynamic systems. It gives insights into the motional behavior of multidomain proteins in their free form and in supramolecular complexes.

Predicting the rotational tumbling of dynamic multidomain proteins and supramolecular complexes

Munari, Francesca;
2013-01-01

Abstract

Time is of the essence: The rotational motion of biomolecules depends on intra- and intermolecular interactions and thus on distinct functional states. A new method, called HYCUD accurately predicts rotational correlation times in complex dynamic systems. It gives insights into the motional behavior of multidomain proteins in their free form and in supramolecular complexes.
2013
NMR spectroscopy; hydrodynamic coupling; protein disorder; proteins; rotational diffusion; Hydrodynamics; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Proteins
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/973710
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