Solid epidemiological evidences connect obesity with incidence, stage, and survival in pancreatic cancer. However, the underlying mechanistic basis linking adipocytes to pancreatic cancer progression remain largely elusive. We hypothesized that factors secreted by adipocytes could be responsible for epithelial-to-mesenchymal transition (EMT) induction and, in turn, a more aggressive phenotype in models of pancreatic preneoplastic lesions.

Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling

Carbone, C;Piro, G;GAIANIGO, NICOLA;Ligorio, F;Santoro, R;Merz, V;Simionato, F;Zecchetto, C;Krampera, M;De Franceschi, L;Scarpa, A;Tortora, G;Melisi, D.
2018-01-01

Abstract

Solid epidemiological evidences connect obesity with incidence, stage, and survival in pancreatic cancer. However, the underlying mechanistic basis linking adipocytes to pancreatic cancer progression remain largely elusive. We hypothesized that factors secreted by adipocytes could be responsible for epithelial-to-mesenchymal transition (EMT) induction and, in turn, a more aggressive phenotype in models of pancreatic preneoplastic lesions.
:BODY-MASS INDEX; STEM-CELLS; OBESITY; RESISTANCE; RISK; MICROENVIRONMENT; ADENOCARCINOMA; METAANALYSIS; EXPRESSION; THERAPY
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/970435
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