Background: Childhood trauma has been significantly associated with first-episode psychosis, affective dysfunction and substance use. Aims: To test whether people wieth first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increasd lifetime rate of substance use. Method: The sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d. = 9.7). Results: Severe sexual abuse was significantly associated with a diagnosis of affective psychosis (χ(2) = 4.9, P = 0.04) and with higher rates of lifetime use of cannabis (68% v 41%; P = 0.02) and heroin (20% v 5%; P = 0.02). Severe physical abuse was associated with increased lifetime use of heroin (15% v 5%; P = 0.03) and cocaine (32% v 17%; P = 0.05). Conclusions: Patients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.
BackgroundChildhood trauma has been significantly associated with first episode psychosis, affective dysfunction and substance use.AimsTo test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use.MethodThe sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d.=9.7).ResultsSevere sexual abuse was significantly associated with a diagnosis of affective psychosis (chi(2)=4.9, P=0.04) and with higher rates of lifetime use of cannabis (68% v. 41%; P=0.02) and heroin (20% V. 5%; P=0.02). Severe physical abuse was associated with increased lifetime use of heroin (15% v. 5%; P=0.03) and cocaine (32% v. 17%; P=0.05).ConclusionsPatients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.
Influence of childhood trauma on diagnosis and substance use in first-episode psychosis
TOMASSI, Simona;TOSATO, Sarah;LASALVIA, Antonio;BONETTO, Chiara;DE SANTI, Katia;CRISTOFALO, Doriana;RUGGERI, Mirella
2017-01-01
Abstract
BackgroundChildhood trauma has been significantly associated with first episode psychosis, affective dysfunction and substance use.AimsTo test whether people with first-episode psychosis who had experienced childhood trauma, when compared with those who had not, showed a higher rate of affective psychosis and an increased lifetime rate of substance use.MethodThe sample comprised 345 participants with first-episode psychosis (58% male, mean age 29.8 years, s.d.=9.7).ResultsSevere sexual abuse was significantly associated with a diagnosis of affective psychosis (chi(2)=4.9, P=0.04) and with higher rates of lifetime use of cannabis (68% v. 41%; P=0.02) and heroin (20% V. 5%; P=0.02). Severe physical abuse was associated with increased lifetime use of heroin (15% v. 5%; P=0.03) and cocaine (32% v. 17%; P=0.05).ConclusionsPatients with first-episode psychosis exposed to childhood trauma appear to constitute a distinctive subgroup in terms of diagnosis and lifetime substance use.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
