Immune thrombocytopenia (ITP) is a rare but well-recognized post-allogeneic hematopoietic stem cell transplant (HSCT) autoimmune complication for which a standard treatment approach is lacking. Herein we report on an adult patient affected by high-risk acute myeloid leukemia (AML) who developed a post-HSCT ITP. Due to the refractoriness to first-line therapies the patient underwent the thrombopoietin (TPO) mimetic Eltrombopag obtaining the ITP resolution. We also discuss the clinical course of ITP in post-HSCT setting and pros and cons of different therapeutic strategies, focusing on the emerging role of TPO mimetics.

IMMUNE THROMBOCYTOPENIA AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: CASE REPORT AND BRIEF OVERVIEW OF TREATMENT STRATEGIES

Ferrarini, Isacco;TECCHIO, Cristina;AMBROSETTI, Achille
2016-01-01

Abstract

Immune thrombocytopenia (ITP) is a rare but well-recognized post-allogeneic hematopoietic stem cell transplant (HSCT) autoimmune complication for which a standard treatment approach is lacking. Herein we report on an adult patient affected by high-risk acute myeloid leukemia (AML) who developed a post-HSCT ITP. Due to the refractoriness to first-line therapies the patient underwent the thrombopoietin (TPO) mimetic Eltrombopag obtaining the ITP resolution. We also discuss the clinical course of ITP in post-HSCT setting and pros and cons of different therapeutic strategies, focusing on the emerging role of TPO mimetics.
2016
Leukemia, Allogeneic stem cell transplantation, Immune thrombocytopenia, Eltrombopag
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/967017
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