Hepcidin is an hormone that regulates iron metabolism and this study highlight for the first time that the gene encoding for hepcidin, HAMP, is regulated transcriptionally by a major epigenetic mechanism, DNA methylation at promoter site.

HEPCIDIN REPRESSION BY PROMOTER DNA HYPERMETHYLATION IN NON-VIRAL HEPATOCELLULAR CARCINOMA

CAMPOSTRINI, Natascia;Udali, Silvia;CORBELLA, Michela;GUARINI, Patrizia;CASTAGNA, Annalisa;PATTINI, Patrizia;RUZZENENTE, Andrea;GUGLIELMI, Alfredo;MORUZZI, Sara;FERRARINI, Alberto;DELLEDONNE, Massimo;PERBELLINI, Luigi;FRANCESCHI, Antonia;GIRELLI, Domenico;FRISO, Simonetta
2016-01-01

Abstract

Hepcidin is an hormone that regulates iron metabolism and this study highlight for the first time that the gene encoding for hepcidin, HAMP, is regulated transcriptionally by a major epigenetic mechanism, DNA methylation at promoter site.
Epigenetics, hepcidin, DNA methylation, HAMP gene, iron metabolism, ferritin, primary liver cancer, hepatocellular carcinoma
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/966171
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