Prevention of BRONJ Using PRGF in a Totally Edentulous Patient Restored With Postextraction Implants: A Case Report

Introduction The aim of this report was to show results of post-extraction implants placed to rehabilitate an atrophic mandible using a protocol based on CTX records and PRGF application in order to prevent BRONJ. Case Presentation A 65-year-old male affected by rheumatoid arthritis who was a chronic consumer of bisphosphonates and methylprednisolone was referred to the authors seeking restoration of his mandible with a full-arch prosthesis. Bisphosphonates were suspended, and the marker for bone turnover (CTX) was recorded every 3 months until it exceeded 200 pg/mL. During surgery, PRGF was applied to all the implant sites and the alveolar ridge before suturing. No complications occurred during the healing period, and no signs or symptoms of BRONJ were detected throughout the 1-year follow-up. Conclusions The protocol described in this report can be a viable solution for preventing BRONJ in a patient who is consuming bisphosphonates and corticosteroids and undergoes implant surgery. Its purpose is to reduce the risk of infection and hasten the healing of bone and soft tissue.