Mitochondrial anion transporter proteins localized into the mitochondrial inner membrane. Currently, five UCP family members have been identified in mammals.Among them, UCP2 is widely distributedthroughout the organism, suggesting different and wide functions for this mitochondrial uncoupling protein. Basically, the antioxidant role of UCP2 is due to its capability to decrease the mitochondrial potential and to dissipate the proton gradient.

The antioxidant mitochondrial protein UCP2 promotes cancer development connecting theWarburg effect and autophagy

CORDANI, MARCO;BUTERA, GIOVANNA;PACCHIANA, Raffaella;DONADELLI, Massimo
2017-01-01

Abstract

Mitochondrial anion transporter proteins localized into the mitochondrial inner membrane. Currently, five UCP family members have been identified in mammals.Among them, UCP2 is widely distributedthroughout the organism, suggesting different and wide functions for this mitochondrial uncoupling protein. Basically, the antioxidant role of UCP2 is due to its capability to decrease the mitochondrial potential and to dissipate the proton gradient.
mitochondrial uncoupling; ROS; Warburg effect; autophagy; cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/959718
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