The timing of Trypanosoma brucei entry into the brain parenchyma to initiate the second, meningoencephalitic stage of human African trypanosomiasis or sleeping sickness is currently debated and even parasite invasion of the neuropil has been recently questioned. Furthermore, the relationship between neurological features and disease stage are unclear, despite the important diagnostic and therapeutic implications.

Trypanosoma brucei invasion and T-cell infiltration of the brain parenchyma in experimental sleeping sickness: timing and correlation with functional changes

LAPERCHIA, Claudia;PALOMBA, Maria;SEKE ETET, PAUL FAUSTIN;BENTIVOGLIO FALES, Marina
2016-01-01

Abstract

The timing of Trypanosoma brucei entry into the brain parenchyma to initiate the second, meningoencephalitic stage of human African trypanosomiasis or sleeping sickness is currently debated and even parasite invasion of the neuropil has been recently questioned. Furthermore, the relationship between neurological features and disease stage are unclear, despite the important diagnostic and therapeutic implications.
Trypanosoma brucei brucei; human African trypanosomiasis; rat model; infection timing; functional changes; disease staging
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/956007
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