Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight. Cancer Discov; 6(8); 821-3. ©2016 AACR.See related article by Incio et al., p. 852.

Adipocytes and Neutrophils Give a Helping Hand to Pancreatic Cancers

Bronte, Vincenzo;TORTORA, GIAMPAOLO
2016-01-01

Abstract

Obesity-induced inflammation can build up a confined microenvironment in pancreatic adenocarcinoma that is associated with increased desmoplasia, neutrophil recruitment, reduced delivery of chemotherapeutic drugs, and immune evasion. Targeting molecular pathways empowering this circuit might represent a necessary measure to reach clinical efficacy for combination therapies in patients with excess body weight. Cancer Discov; 6(8); 821-3. ©2016 AACR.See related article by Incio et al., p. 852.
2016
PANCREATIC
CANCER, ADYPOCYTES, NEUTROPHILS
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/955530
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