Luminescence thermal sensing and deep-tissue imaging using nanomaterials operating within the first biological window (ca. 700-980 nm) are of great interest, prompted by the ever-growing demands in the fields of nanotechnology and nanomedicine. Here, we show that (Gd1-xNdx)2O3 (x = 0.009, 0.024 and 0.049) nanorods exhibit one of the highest thermal sensitivity and temperature uncertainty reported so far (1.75 ± 0.04% K-1 and 0.14 ± 0.05 K, respectively) for a nanothermometer operating in the first transparent near infrared window at temperatures in the physiological range. This sensitivity value is achieved using a common R928 photomultiplier tube that allows defining the thermometric parameter as the integrated intensity ratio between the 4F5/2 → 4I9/2 and 4F3/2 → 4I9/2 transitions (with an energy difference between the barycentres of the two transitions >1000 cm-1). Moreover, the measured sensitivity is one order of magnitude higher than the values reported so far for Nd3+-based nanothermometers enlarging, therefore, the potential of using Nd3+ ions in luminescence thermal sensing and deep-tissue imaging.

Boosting the sensitivity of Nd3+-based luminescent nanothermometers

BETTINELLI, Marco Giovanni;
2015-01-01

Abstract

Luminescence thermal sensing and deep-tissue imaging using nanomaterials operating within the first biological window (ca. 700-980 nm) are of great interest, prompted by the ever-growing demands in the fields of nanotechnology and nanomedicine. Here, we show that (Gd1-xNdx)2O3 (x = 0.009, 0.024 and 0.049) nanorods exhibit one of the highest thermal sensitivity and temperature uncertainty reported so far (1.75 ± 0.04% K-1 and 0.14 ± 0.05 K, respectively) for a nanothermometer operating in the first transparent near infrared window at temperatures in the physiological range. This sensitivity value is achieved using a common R928 photomultiplier tube that allows defining the thermometric parameter as the integrated intensity ratio between the 4F5/2 → 4I9/2 and 4F3/2 → 4I9/2 transitions (with an energy difference between the barycentres of the two transitions >1000 cm-1). Moreover, the measured sensitivity is one order of magnitude higher than the values reported so far for Nd3+-based nanothermometers enlarging, therefore, the potential of using Nd3+ ions in luminescence thermal sensing and deep-tissue imaging.
Infrared devices; Medical nanotechnology; Nanorods
File in questo prodotto:
File Dimensione Formato  
balabhadra2015.pdf

solo utenti autorizzati

Licenza: Accesso ristretto
Dimensione 1.23 MB
Formato Adobe PDF
1.23 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/955350
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 178
  • ???jsp.display-item.citation.isi??? 173
social impact