The management of pT1a-b pN0 HER2-positive breast cancer is controversial and no data about the efficacy of trastuzumab in this setting are available from randomized clinical trials. The aims of this retrospective study were to assess how patients are managed in clinical practice in Italy, which clinical or biological characteristics influenced the choice of adjuvant systemic therapy and the outcome of patients.

The Promher Study: An Observational Italian Study on Adjuvant Therapy for HER2-Positive, pT1a-b pN0 Breast Cancer

FIORIO, Elena;Ferro, Antonella;Gulisano, Marcella;Bria, Emilio;
2015-01-01

Abstract

The management of pT1a-b pN0 HER2-positive breast cancer is controversial and no data about the efficacy of trastuzumab in this setting are available from randomized clinical trials. The aims of this retrospective study were to assess how patients are managed in clinical practice in Italy, which clinical or biological characteristics influenced the choice of adjuvant systemic therapy and the outcome of patients.
2015
Adjuvants, Pharmaceutic; Adult; Age Factors; Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Disease Management; Female; Gene Expression; Humans; Middle Aged; Multivariate Analysis; Neoplasm Proteins; Prognosis; Receptor, ErbB-2; Retrospective Studies; Survival Analysis; Trastuzumab; Tumor Burden
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/953659
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