Angiogenesis plays a major role in the development and progression of solid tumors, including lung cancer. Although some anti-angiogenic agents have demonstrated a statistically significant advantage in terms of primary outcome in clinical trials, the reliable clinical benefit obtained with these drugs is still questionable and often quantitatively limited. To better clarify this complex scenario and definitively establish the concrete benefits of anti-angiogenic strategies in lung cancer, several clinical trials have been conducted with others currently ongoing.

An overview of angiogenesis inhibitors in Phase II studies for non-small-cell lung cancer

PILOTTO, Sara;Peretti, Umberto;Kinspergher, Stefania;Milella, Michele;Carbognin, Luisa;Ferrara, Roberto;CACCESE, MARIO;TORTORA, GIAMPAOLO;Bria, Emilio
2015

Abstract

Angiogenesis plays a major role in the development and progression of solid tumors, including lung cancer. Although some anti-angiogenic agents have demonstrated a statistically significant advantage in terms of primary outcome in clinical trials, the reliable clinical benefit obtained with these drugs is still questionable and often quantitatively limited. To better clarify this complex scenario and definitively establish the concrete benefits of anti-angiogenic strategies in lung cancer, several clinical trials have been conducted with others currently ongoing.
Phase II; angiogenesis; lung cancer; review; Angiogenesis Inhibitors; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Drug Design; Drug Repositioning; Humans; Lung Neoplasms; Neovascularization, Pathologic
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/953646
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