The resistance to selective EGFR inhibitors involves the activation of alternative signaling pathways, and Akt activation and VEGF induction have been described in EGFR inhibitor-resistant tumors. Combined inhibition of EGFR and other signaling proteins has become a successful therapeutic approach, stimulating the search for further determinants of resistance as basis for novel therapeutic strategies.

Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells

BIANCO, ROBERTO;MELISI, Davide;TORTORA, GIAMPAOLO
2008-01-01

Abstract

The resistance to selective EGFR inhibitors involves the activation of alternative signaling pathways, and Akt activation and VEGF induction have been described in EGFR inhibitor-resistant tumors. Combined inhibition of EGFR and other signaling proteins has become a successful therapeutic approach, stimulating the search for further determinants of resistance as basis for novel therapeutic strategies.
2008
Antineoplastic Agents; Blotting, Western; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Immunoprecipitation; Neoplasms; Piperidines; Quinazolines; RNA Interference; Receptor, Epidermal Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Vascular Endothelial Growth Factor Receptor-1
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/952796
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