INTRODUCTION AND OBJECTIVES Purpose of the study is to assess through generic and IONB-specific questionnaires HRQoL in BCa patients who received RC with IONB reconstruction. METHODS we performed a multicenter, cross-sectional analysis of 171 RC-IONB patients. Patients completed the following questionnaires: the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder cancer-specific instruments (QLQ-BLM30) and the IONB–Patient Reported Outcome (IONB –PRO) questionnaire. Linear/Logistic regression models tested the association between clinic-pathological variables and HRQOL domain scores and the presence of independent predictors of local recurrence and urinary incontinence. RESULTS Mean age was 60.04 and 156/171 (91.2%) were male patients. Mean follow-up period was 51.72 months. Most frequently reported concomitant medical conditions were: grade I renal impairment, grade I cardiac insufficiency, hypertension. Increasing age (p <0.006) and urinary incontinence (p <0.003) resulted significantly related to a deteriorating overall quality of life. Sex (OR=0.167, p=0.012), presence of hypertension at baseline (OR=3.464, p=0.001) and age (OR=1.046, p 0.016) were independent predictors of urinary incontinence while sex (OR=0.051, p=0.046), BMI (OR=0.543, p=0.001), presence of renal impairment at baseline (OR=0.009, p<0.001), and presence of peripheral vascular disease at baseline (OR=0.044, p=0.003) resulted independent predictors of disease recurrence. CONCLUSIONS Our analysis shows that post-RC IONB patients have a mild to moderate impairment of their HRQoL when investigated by means of generic and disease specific instruments and a more pronounced impairment when investigated with the IONB-PRO specific instrument. Age, comorbidities and post-operative pathologic factors may influence HRQoL and should be considered in pre- and post-operative counseling.
QUALITY OF LIFE ASSESSMENT WITH ORTHOTOPIC ILEAL NEOBLADDER RECONSTRUCTION AFTER RADICAL CYSTECTOMY: RESULTS FROM A PROSPECTIVE ITALIAN MULTICENTER OBSERVATIONAL STUDY
CERRUTO, Maria Angela;LONARDI, Cristina;
2015-01-01
Abstract
INTRODUCTION AND OBJECTIVES Purpose of the study is to assess through generic and IONB-specific questionnaires HRQoL in BCa patients who received RC with IONB reconstruction. METHODS we performed a multicenter, cross-sectional analysis of 171 RC-IONB patients. Patients completed the following questionnaires: the European Organisation for Research and Treatment of Cancer (EORTC) generic (QLQ-C30) and bladder cancer-specific instruments (QLQ-BLM30) and the IONB–Patient Reported Outcome (IONB –PRO) questionnaire. Linear/Logistic regression models tested the association between clinic-pathological variables and HRQOL domain scores and the presence of independent predictors of local recurrence and urinary incontinence. RESULTS Mean age was 60.04 and 156/171 (91.2%) were male patients. Mean follow-up period was 51.72 months. Most frequently reported concomitant medical conditions were: grade I renal impairment, grade I cardiac insufficiency, hypertension. Increasing age (p <0.006) and urinary incontinence (p <0.003) resulted significantly related to a deteriorating overall quality of life. Sex (OR=0.167, p=0.012), presence of hypertension at baseline (OR=3.464, p=0.001) and age (OR=1.046, p 0.016) were independent predictors of urinary incontinence while sex (OR=0.051, p=0.046), BMI (OR=0.543, p=0.001), presence of renal impairment at baseline (OR=0.009, p<0.001), and presence of peripheral vascular disease at baseline (OR=0.044, p=0.003) resulted independent predictors of disease recurrence. CONCLUSIONS Our analysis shows that post-RC IONB patients have a mild to moderate impairment of their HRQoL when investigated by means of generic and disease specific instruments and a more pronounced impairment when investigated with the IONB-PRO specific instrument. Age, comorbidities and post-operative pathologic factors may influence HRQoL and should be considered in pre- and post-operative counseling.
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