Introduction: Women undergoing urinary radical cystectomy (RC) and urinary diversion for bladder cancer have some early and late complications and experience substantial limitations in health-related quality of life (HRQoL). At present, there are sparse studies that have evaluated the levels of discomfort in long-term survivors (1-3). In the present study, we used the validated Italian version of QLQ-BLM30 and QLQ-C30 from European Organisation for Research and Treatment of Cancer (EORTC) to assess bladder cancer-specific HRQoL between patients with bladder cancer undergoing Ileal othotopic neobladder (IONB) and ileal conduit (IC) after RC and with long term follow-up. Patients and Methods: From June 2007 to September 2013, we evaluated 48 females with bladder cancer in five urological academic centres. In this study, we retrospectively analyzed the HRQoL in 33 women undergoing IC and in 15 females with IONB; all patients had no evidence of tumor recurrence and were actively followed up. Questionnaire results were analyzed in order to evaluate the HRQoL in women undergoing IONB and IC. Mean values with standard deviations (±SD) were computed for all items. The Wilcoxon two sample test was used to verify differences. Statistical significance was achieved if p -value was ≤0.05 (two-sides). Results: The median age of patients with IONB was 56 years (range=44-81) and 71 years in those with IC (range=52-86). The median of follow-up was 39 months (range=16-120) in those with an IONB and 40 months (range=6-153) in the 33 remaining women with IC. Our data showed that patients with IC had a better physical functioning (higer score means a better functionality) in comparison to those with IONB (75.4±24.0 and 58.2±20.8, respectively; p= 0.008) as well in social functioning (80.3±23.7 and 60.0±23.4, respectively; p= 0.01). In addition women with IC had fewer symptoms (lower score means a low level of symptomatology/problems), such as nausea and vomiting in comparison with those with IONB (2.5±7.4 and 12.2±16.0, respectively; p= 0.008) and also had lower financial difficulties (10.1±17.6 and 31.1±36.7, respectively; p= 0.04). Discussion: Our study, based on long-term follow-up, showed a better physical and social functioning, less symptoms, such as nausea and vomiting, and reduced financial difficulties patients with IC in comparison with patients undergoing IONB. Conclusion: Patients with IONB have a negative impact on HRQoL in comparison with patients with IC.
|Titolo:||HRQOL IN 48 WOMEN UNDERGOING ILEAL ORTHOTOPIC NEOBLADDER AND ILEAL CONDUIT: EVALUATION IN LONG-TERM SURVIVORS|
|Data di pubblicazione:||2015|
|Appare nelle tipologie:||01.05 Abstract in rivista|