Arterial spin labeling can be very useful for the detection of perfusion changes in drug-resistant focal epilepsy. In order to identify regions related to the epileptic focus, quantification of CBF and a statistical analysis were computed in each patient and compared with a template of normal perfusion. A seed-driven connectivity was also used to identify networks regions that are differently organized in epileptic patients compared to healthy subjects. The investigation allowed us to correctly identify the epileptogenic zone in patients, in whom the results were confirmed by surgical resection and subsequent seizure freedom.
Resting-state cerebral blood flow and functional connectivity in focal epilepsy as assessed by arterial spin labeling
STORTI, Silvia Francesca;PIZZINI, Francesca;BELTRAMELLO, ALBERTO;
2014-01-01
Abstract
Arterial spin labeling can be very useful for the detection of perfusion changes in drug-resistant focal epilepsy. In order to identify regions related to the epileptic focus, quantification of CBF and a statistical analysis were computed in each patient and compared with a template of normal perfusion. A seed-driven connectivity was also used to identify networks regions that are differently organized in epileptic patients compared to healthy subjects. The investigation allowed us to correctly identify the epileptogenic zone in patients, in whom the results were confirmed by surgical resection and subsequent seizure freedom.
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