PBMCs from HL and B-cell NHL patients contain a population of CD66b+CD33dimHLA-DR- G-MDSCs, mostly composed of activated low-density neutrophils with immunosuppressive properties. These findings disclose a previously unknown G-MDSC-mediated mechanism of immune-escape in lymphomas, therefore anticipating possible targets for therapeutic interventions.
Identification of granulocytic myeloid-derived suppressor cells (G-MDSCs) in the peripheral blood of Hodgkin and non-Hodgkin lymphoma patients.
Marini, Olivia;SPINA, CRISTINA;MIMIOLA, Elda;Cassaro, Adriana;MALERBA, Giovanni;TODESCHINI, Giuseppe;PERBELLINI, Omar;SCUPOLI, Maria;CARLI, Giuseppe;FACCHINELLI, DAVIDE;CASSATELLA, Marco Antonio;SCAPINI, Patrizia;TECCHIO, Cristina
2016-01-01
Abstract
PBMCs from HL and B-cell NHL patients contain a population of CD66b+CD33dimHLA-DR- G-MDSCs, mostly composed of activated low-density neutrophils with immunosuppressive properties. These findings disclose a previously unknown G-MDSC-mediated mechanism of immune-escape in lymphomas, therefore anticipating possible targets for therapeutic interventions.
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