The aim of this study was to evaluate DNA damage in response to increasing bulks of aerobic physical exercise. Fifteen adult and trained athletes performed four sequential trials with increasing running distance (5-, 10-, 21- and 42-km) in different periods of the year. The gamma-H2AX foci parameters were analyzed before and 3 h after the end of each trial. The values of all gamma-H2AX foci parameters were enhanced after the end of each trial, with values gradually increasing from the 5- to the 42-km trial. Interestingly, a minor increase of gamma-H2AX foci was still evident after 5- to 10-km running, but a much higher increase occurred when the running distance exceeded 21 km. The generation of DNA injury was then magnified by running up to 42-km. The increase of each gamma-H2AX foci parameter was then found to be associated with both running distance and average intensity. In multivariate linear regression analysis, the running distance was significantly associated with average intensity and post-run variation in the percentage of cells with gamma-H2AX foci. We can hence conclude that aerobic exercise may generate an acute DNA damage in trained athletes, which is highly dependent upon running distance and average intensity. (C) 2016 Elsevier B.V. All rights reserved.
|Titolo:||DNA injury is acutely enhanced in response to increasing bulks of aerobic physical exercise|
LIPPI, Giuseppe (Corresponding)
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||01.01 Articolo in Rivista|