Background & aims: Vitamin K acts as a coenzyme in the g-carboxylation of vitamin K-dependent proteins,including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific6 (GAS6) protein. Osteocalcin is a key factor for bone matrix formation. MGP is a local inhibitor of softtissue calcification. GAS6 activity prevents the apoptosis of vascular smooth muscle cells. Few data onvitamin K intake in chronic kidney disease patients and no data in patients on a Mediterranean diet areavailable. In the present study, we evaluate the dietary intake of vitamin K1 in a cohort of patientsundergoing haemodialysis.Methods: In this multi-centre controlled observational study, data were collected from 91 patients aged>18 years on dialysis treatment for at least 12 months and from 85 age-matched control subjects withnormal renal function. Participants completed a food journal of seven consecutive days for the estimationof dietary intakes of macro- and micro-nutrients (minerals and vitamins).Results: Compared to controls, dialysis patients had a significant lower total energy intake, along with alower dietary intake of proteins, fats, carbohydrates, fibres, and of all the examined minerals (Ca, P, Fe,Na, K, Zn, Cu, and Mg). With the exception of vitamin B12, vitamins intake followed a similar pattern,with a lower intake in vitamin A, B1, B2, C, D, E, folates, K1 and PP. These finding were confirmed alsowhen normalized for total energy intake or for body weight.In respect to the adequate intakes recommended in the literature, the prevalence of a deficient vitamin Kintake was very high (70e90%) and roughly double than in controls. Multivariate logistic model identifiedvitamin A and iron intake as predictors of vitamin K deficiency.

Low vitamin K1 intake in haemodialysis patients

ROSSINI, Maurizio;
2017-01-01

Abstract

Background & aims: Vitamin K acts as a coenzyme in the g-carboxylation of vitamin K-dependent proteins,including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific6 (GAS6) protein. Osteocalcin is a key factor for bone matrix formation. MGP is a local inhibitor of softtissue calcification. GAS6 activity prevents the apoptosis of vascular smooth muscle cells. Few data onvitamin K intake in chronic kidney disease patients and no data in patients on a Mediterranean diet areavailable. In the present study, we evaluate the dietary intake of vitamin K1 in a cohort of patientsundergoing haemodialysis.Methods: In this multi-centre controlled observational study, data were collected from 91 patients aged>18 years on dialysis treatment for at least 12 months and from 85 age-matched control subjects withnormal renal function. Participants completed a food journal of seven consecutive days for the estimationof dietary intakes of macro- and micro-nutrients (minerals and vitamins).Results: Compared to controls, dialysis patients had a significant lower total energy intake, along with alower dietary intake of proteins, fats, carbohydrates, fibres, and of all the examined minerals (Ca, P, Fe,Na, K, Zn, Cu, and Mg). With the exception of vitamin B12, vitamins intake followed a similar pattern,with a lower intake in vitamin A, B1, B2, C, D, E, folates, K1 and PP. These finding were confirmed alsowhen normalized for total energy intake or for body weight.In respect to the adequate intakes recommended in the literature, the prevalence of a deficient vitamin Kintake was very high (70e90%) and roughly double than in controls. Multivariate logistic model identifiedvitamin A and iron intake as predictors of vitamin K deficiency.
2017
Dialysis; Diet; Haemodialysis; Menaquinone; Nutrition; Phylloquinone
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/944738
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