A radioautographic study shows for the first time that exogenously administered cyclic AMP increases the nucleolar uptake of radioactive cortisol in hepatocytes but not in fibroblast-like cells. Conversely, exogenously administered cortisol decreases the nuclear uptake of radioactive cyclic AMP while increases its uptake in the cytoplasm.
A radioautographic study on the mechanisms by which adrenal glucocorticoids play their permissive role in the biological activity of cyclic AMP in the liver cell
ARMATO, Ubaldo;
1974-01-01
Abstract
A radioautographic study shows for the first time that exogenously administered cyclic AMP increases the nucleolar uptake of radioactive cortisol in hepatocytes but not in fibroblast-like cells. Conversely, exogenously administered cortisol decreases the nuclear uptake of radioactive cyclic AMP while increases its uptake in the cytoplasm.
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