Drug induced liver injury is one of the most serious adverse drug reactions and the most frequent reason of restriction of indications or withdrawal of drugs. Some NSAIDs were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use ≥ 5%.
Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug-induced liver injury case-control study in Italy
CONFORTI, Anita;BORTOLAMI, Oscar;MORETTI, Ugo;Arzenton, Elena;LEONE, Roberto
2016-01-01
Abstract
Drug induced liver injury is one of the most serious adverse drug reactions and the most frequent reason of restriction of indications or withdrawal of drugs. Some NSAIDs were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with a prevalence of use ≥ 5%.
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