Small molecule therapeutic drugs must reach their intended cellular targets(pharmacokinetics) and engage them to modulate therapeutic effects (pharmacodynamics).These processes are often difficult to measure in vivo due to their complexities andoccurrence within single cells. It has been particularly difficult to directly measure cellulardrug target binding.
Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement
FUMENE FERUGLIO, Paolo;
2016-01-01
Abstract
Small molecule therapeutic drugs must reach their intended cellular targets(pharmacokinetics) and engage them to modulate therapeutic effects (pharmacodynamics).These processes are often difficult to measure in vivo due to their complexities andoccurrence within single cells. It has been particularly difficult to directly measure cellulardrug target binding.
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