Small molecule therapeutic drugs must reach their intended cellular targets(pharmacokinetics) and engage them to modulate therapeutic effects (pharmacodynamics).These processes are often difficult to measure in vivo due to their complexities andoccurrence within single cells. It has been particularly difficult to directly measure cellulardrug target binding.

Two-Photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement

FUMENE FERUGLIO, Paolo;
2016-01-01

Abstract

Small molecule therapeutic drugs must reach their intended cellular targets(pharmacokinetics) and engage them to modulate therapeutic effects (pharmacodynamics).These processes are often difficult to measure in vivo due to their complexities andoccurrence within single cells. It has been particularly difficult to directly measure cellulardrug target binding.
2016
Two phton, fluorescence anisotropy, drug engagement
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/938273
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