In this work, we investigated whether the structural properties of cortico-subcortical (CS) motor circuits are related to motor outcome after stroke. To do this, we acquired Diffusion Spectrum Imaging data in 10 stroke patients at 3 time points after stroke. We then performed tractographic reconstruction and estimated a number of microstructural indices, derived from the 3D Simple Harmonic Oscillator based Reconstruction and Estimation (SHORE) model, in the cortico-subcortical motor fiber tracts. Linear regression analysis showed that SHORE metrics of thalamo-cortical and intrastriatal connections in the first week after stroke are strongly related to stroke recovery at 6 months follow-up.

Cortico-Subcortical motor network integrity relates to functional recovery after stroke

OBERTINO, SILVIA;Brusini, Lorenza;Zucchelli, Mauro;DADUCCI, Alessandro;MENEGAZ, Gloria;
2016-01-01

Abstract

In this work, we investigated whether the structural properties of cortico-subcortical (CS) motor circuits are related to motor outcome after stroke. To do this, we acquired Diffusion Spectrum Imaging data in 10 stroke patients at 3 time points after stroke. We then performed tractographic reconstruction and estimated a number of microstructural indices, derived from the 3D Simple Harmonic Oscillator based Reconstruction and Estimation (SHORE) model, in the cortico-subcortical motor fiber tracts. Linear regression analysis showed that SHORE metrics of thalamo-cortical and intrastriatal connections in the first week after stroke are strongly related to stroke recovery at 6 months follow-up.
Diffusion MRI, microstructure, biomarkers, stroke, plasticity
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/935806
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