In this work we aim at investigating the 3D Simple Harmonic Oscillator based Reconstruction and Estimation3 (3D-SHORE) derived numerical biomarkers for tractometry. In particular, we target the subcortical motor network (SC-MN) of a healthy subject. Using diffusion spectrum imaging (DSI) we reconstructed the SC-MN and compared the resulting information about white matter (WM) density and structure with that provided by Generalized Fractional Anisotropy (GFA) and Magnetization Transfer Ratio (MTR) imaging. The SC-MN gathers the connections between the cortical motor area, the basal ganglia and the thalamus, and it essentially consists of three major subcortical networks (Figure 1): i) the sensory-motor sub-loop (primary and sensory motor areas - putamen- globus pallidus - ventral lateral thalamic nucleus - motor cortex), ii) the premotor sub-loop (premotor dorsal and ventral areas (dPM, vPM) - caudate nucleus - putamen, globus pallidus –ventral anterior thalamic nuleus - premotor cortex iii) the supplementary motor area (SMA) sub-loop (SMA - putamen and caudatus - globus pallidus - ventral anterior and the ventro - lateral thalamic nuclei - SMA).
Analysis of GFA changes along the subcortical motor network after stroke
OBERTINO, SILVIA;DADUCCI, Alessandro;MENEGAZ, Gloria
2016-01-01
Abstract
In this work we aim at investigating the 3D Simple Harmonic Oscillator based Reconstruction and Estimation3 (3D-SHORE) derived numerical biomarkers for tractometry. In particular, we target the subcortical motor network (SC-MN) of a healthy subject. Using diffusion spectrum imaging (DSI) we reconstructed the SC-MN and compared the resulting information about white matter (WM) density and structure with that provided by Generalized Fractional Anisotropy (GFA) and Magnetization Transfer Ratio (MTR) imaging. The SC-MN gathers the connections between the cortical motor area, the basal ganglia and the thalamus, and it essentially consists of three major subcortical networks (Figure 1): i) the sensory-motor sub-loop (primary and sensory motor areas - putamen- globus pallidus - ventral lateral thalamic nucleus - motor cortex), ii) the premotor sub-loop (premotor dorsal and ventral areas (dPM, vPM) - caudate nucleus - putamen, globus pallidus –ventral anterior thalamic nuleus - premotor cortex iii) the supplementary motor area (SMA) sub-loop (SMA - putamen and caudatus - globus pallidus - ventral anterior and the ventro - lateral thalamic nuclei - SMA).
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