Lyme arthritis (LA) is characterized by infiltration of inflammatory cells, mainly neutrophils (polymorphonuclear cells [PMNs]) and T cells, into the joints. This study was undertaken to evaluate the role of the neutrophil-activating protein A (NapA) of Borrelia burgdorferi in eliciting inflammation and in driving the adaptive immune response.

Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi-induced arthritis by neutrophil-activating protein A

MICHELETTI, Alessandra;CASSATELLA, Marco Antonio;
2013-01-01

Abstract

Lyme arthritis (LA) is characterized by infiltration of inflammatory cells, mainly neutrophils (polymorphonuclear cells [PMNs]) and T cells, into the joints. This study was undertaken to evaluate the role of the neutrophil-activating protein A (NapA) of Borrelia burgdorferi in eliciting inflammation and in driving the adaptive immune response.
2013
Adaptive Immunity; Animals; Arthritis, Infectious; Arthritis, Rheumatoid; Bacterial Proteins; Borrelia burgdorferi; Chemokines; Chemokines, CXC; Chemotaxis; Female; Flow Cytometry; Humans; Injections, Intra-Articular; Knee Joint; Lyme Disease; Male; Middle Aged; Neutrophil Infiltration; Neutrophils; Rats; Stifle; Synovial Fluid; Synovial Membrane; T-Lymphocytes
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/933315
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 34
  • ???jsp.display-item.citation.isi??? 29
social impact