Fracture is the major complication of osteoporosis, and it allows the identification of individuals needing medical intervention for osteoporosis. After nonvertebral fracture, patients often do not receive osteoporosis medical treatment despite evidence that this treatment reduces the risk of subsequent fracture. In this pre planned analysis of the results of the three-year, placebo-controlled FREEDOM trial, we evaluated the effect of denosumab administration on fracture-healing to address theoretical concerns related to initiating or continuing denosumab therapy in patients presenting with a nonvertebral fracture.

Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing: results from the FREEDOM trial

ADAMI, Silvano;
2012-01-01

Abstract

Fracture is the major complication of osteoporosis, and it allows the identification of individuals needing medical intervention for osteoporosis. After nonvertebral fracture, patients often do not receive osteoporosis medical treatment despite evidence that this treatment reduces the risk of subsequent fracture. In this pre planned analysis of the results of the three-year, placebo-controlled FREEDOM trial, we evaluated the effect of denosumab administration on fracture-healing to address theoretical concerns related to initiating or continuing denosumab therapy in patients presenting with a nonvertebral fracture.
Absorptiometry, Photon; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Bone Density; Bone Density Conservation Agents; Chi-Square Distribution; Denosumab; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Fracture Fixation, Internal; Fracture Healing; Fractures, Spontaneous; Humans; Injections, Subcutaneous; Middle Aged; Osteoporosis, Postmenopausal; Prospective Studies; Reference Values; Risk Assessment; Spinal Fractures; Treatment Outcome
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/933072
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