ACTH can induce the de novo DNA synthesis and the proliferation of normal adult human adrenocortical cells from zonae fasciculata and reticularis. The dose-related changes in the intensity of the incorporation of 3H-thymidine into DNA and of the mitogenic effects observed are likely due to complex hormonal mechanisms that need further study.
Dose-related persistent proliferogenic action of corticotrophin 1-24 in normal adult human adrenocortical cells in primary tissue culture
ARMATO, Ubaldo;
1977-01-01
Abstract
ACTH can induce the de novo DNA synthesis and the proliferation of normal adult human adrenocortical cells from zonae fasciculata and reticularis. The dose-related changes in the intensity of the incorporation of 3H-thymidine into DNA and of the mitogenic effects observed are likely due to complex hormonal mechanisms that need further study.
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