Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: preliminary analysis of a multicentre study

Macrì, Antonio; Arcoraci, Vincenzo; Belgrano, Valerio; Caldana, Marina; Cioppa, Tommaso; Costantini, Barbara; Cucinotta, Eugenio; De Cian, Franco; De Iaco, Pierandrea; De Manzoni, Giovanni; Di Giorgio, Angelo; Fleres, Francesco; Muffatti, Francesca; Orsenigo, Elena; Pinna, Antonio Daniele; Roviello, Franco; Sammartino, Paolo; Scambia, Giovanni; Saladino, Edoardo

Aim: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy. Patients and Methods: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. Results: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity. Conclusion: Careful patient selection has to be performed to improve clinical outcomes.

Titolo:	Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: preliminary analysis of a multicentre study
Autori:	Macrì, Antonio Arcoraci, Vincenzo Belgrano, Valerio Caldana, Marina Cioppa, Tommaso Costantini, Barbara Cucinotta, Eugenio De Cian, Franco De Iaco, Pierandrea DE MANZONI, Giovanni Di Giorgio, Angelo Fleres, Francesco Muffatti, Francesca Orsenigo, Elena Pinna, Antonio Daniele Roviello, Franco Sammartino, Paolo Scambia, Giovanni Saladino, Edoardo mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	ANTICANCER RESEARCH
Abstract:	Aim: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy. Patients and Methods: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. Results: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity. Conclusion: Careful patient selection has to be performed to improve clinical outcomes.
Handle:	http://hdl.handle.net/11562/932052
Appare nelle tipologie:	01.01 Articolo in Rivista

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