Molecularly imprinted polymer (MIP) technique is a powerful mean to produce tailor made synthetic recognition sites. Here precipitation polymerization was exploited to produce a library of MIP nanoparticles (NPs) targeting the N terminus of the hormone Hepcidin-25, whose serum levels correlate with iron dis-metabolisms and doping. Biotinylated MIP NPs were immobilized to NeutrAvidin™ SPR sensor chip. The response of the MIP NP sensor to Hepcidin-25 was studied.

Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25

CENCI, Lucia;Andreetto, Erika;Vestri, Ambra;BOVI, Michele;BUSATO, MIRKO;CASTAGNA, Annalisa;GIRELLI, Domenico;BOSSI, Alessandra Maria
2015-01-01

Abstract

Molecularly imprinted polymer (MIP) technique is a powerful mean to produce tailor made synthetic recognition sites. Here precipitation polymerization was exploited to produce a library of MIP nanoparticles (NPs) targeting the N terminus of the hormone Hepcidin-25, whose serum levels correlate with iron dis-metabolisms and doping. Biotinylated MIP NPs were immobilized to NeutrAvidin™ SPR sensor chip. The response of the MIP NP sensor to Hepcidin-25 was studied.
2015
Molecularly imprinted polymers, Nanoparticles, Hepcidin, Biosensor, Surface plasmon resonance, Ironmetabolism
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/930432
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